[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
April 26, 2006

Excess Dosing of Antithrombotic Therapy in Non–ST-Segment Elevation Acute Coronary Syndromes

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(16):1896-1897. doi:10.1001/jama.295.16.1896-a

To the Editor: Dr Alexander and colleagues1 studied excess dosing of antithrombotic therapy in patients with non–ST-segment elevation acute coronary syndromes. We support their conclusions that this occurs frequently and is associated with major bleeding. However, it is possible that the finding of a nonsignificant adjusted odds ratio for any excess dose of unfractionated heparin (1.08; 95% confidence interval, 0.94-1.26), which was also lower than that for other antithrombotic agents, was primarily related to the inherent difficulty in defining an excess dose regimen.

First Page Preview View Large
First page PDF preview
First page PDF preview