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April 26, 2006

Excess Dosing of Antithrombotic Therapy in Non–ST-Segment Elevation Acute Coronary Syndromes

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(16):1896-1897. doi:10.1001/jama.295.16.1896-b

To the Editor: The study on excess dosing of antithrombotic therapies in patients with non–ST-segment elevation acute coronary syndromes by Dr Alexander and colleagues1 did not examine the use of other antithrombotic treatments, such as aspirin or clopidogrel, whereas these drugs are recommended in the treatment of these syndromes.2,3 Increased bleeding risk could have been associated with the combined use of these antithrombotic medications, and such potential confounding should be considered.

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