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Medical News and Perspectives
April 26, 2006

Mixed Success Found for Avian Flu Vaccine

JAMA. 2006;295(16):1886. doi:10.1001/jama.295.16.1886

An experimental vaccine made from an inactivated H5N1 avian influenza virus can induce immune responses in more than half of healthy adults tested, but requires 2 doses of vaccine each of which is 6 times the dose of that used in a standard influenza shot to have this effect, according to results of a randomized multicenter trial (Treanor JJ et al. N Engl J Med. 2006;354:1343-1351). The findings provide some hope for the control of a potential pandemic, but a more effective vaccine given at lower doses will be needed to meet the world's demands should such a pandemic occur.

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