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May 17, 2006

Prevention of Atrial Fibrillation Following Cardiac Surgery

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(19):2247-2248. doi:10.1001/jama.295.19.2247-b

To the Editor: In their randomized controlled trial of prophylactic amiodarone therapy for the prevention of atrial fibrillation after heart surgery, Dr Mitchell and colleagues1 found that treatment with amiodarone compared with placebo resulted in a 48% reduction in the primary end point, defined as an atrial tachyarrhythmia lasting 5 minutes or longer that prompted treatment by the attending physician. We have a number of questions related to the study design and analysis.