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May 24/31, 2006

Trojan Horse Hypothesis: Inhaled Airborne Particles, Lipid Bullets, and Atherogenesis

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(20):2354-2355. doi:10.1001/jama.295.20.2354-a

To the Editor: In their Preliminary Communication, Dr Sun and colleagues1 showed that in apolipoprotein E knockout mice, exposure to concentrated ambient particles potentiated atherosclerosis under a condition of a high-fat diet. These observations suggest a Trojan horse hypothesis that could explain involvement of microparticles in atherogenesis.

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