Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: In their Preliminary Communication, Dr Sun and colleagues1 showed that in apolipoprotein E knockout mice, exposure to concentrated ambient particles potentiated atherosclerosis under a condition of a high-fat diet. These observations suggest a Trojan horse hypothesis that could explain involvement of microparticles in atherogenesis.
Twickler M, Dallinga-Thie G, Cramer M. Trojan Horse Hypothesis: Inhaled Airborne Particles, Lipid Bullets, and Atherogenesis. JAMA. 2006;295(20):2354-2355. doi:10.1001/jama.295.20.2354-a