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June 7, 2006

Statins, Diet, and Low Cholesterol

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(21):2479-2480. doi:10.1001/jama.295.21.2479-b

To the Editor: In his Editorial discussing recent trials of statins, Dr Cannon1 did not address some of the remaining questions. First, the 4 contemporaneous trials discussed (PROVE IT-TIMI 22,2 A to Z,3 TNT,4 and, now, the IDEAL trial5) have failed to show a reduction in all-cause mortality despite the use of aggressive and higher doses. Second, while previous concerns about increased incidence of cancer and other noncardiac deaths have been somewhat allayed in careful post hoc analysis in these studies, the number of participants who developed cancer in each of these trials may have been too small to find significant differences.

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