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August 9, 2006

Effect of Rimonabant on Weight and Cardiometabolic Risk Factors—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(6):649-651. doi:10.1001/jama.296.6.650

In Reply: Patients were not excluded from the RIO trials based on their baseline Hospital Anxiety and Depression score. As shown in the Table, 272 patients had a subscore for depression between 8 and 10, and 64 had a subscore of 11 or higher at baseline in the RIO studies. However, consistent with National Institutes of Health recommendations,1 patients for whom weight loss therapy is not appropriate were not entered in the study (patients with a serious uncontrolled psychiatric illness such as major uncontrolled depression).

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