Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: Reduced bone mass and increased risk of fracture have been associated with inflammatory diseases such as rheumatoid arthritis,1 inflammatory bowel disease,2 and ankylosing spondylitis.3 Inflammatory cytokines stimulate osteoclastic bone resorption4 and inhibit osteoblast function.5 We hypothesized that serum high-sensitivity C-reactive protein (hsCRP), a marker of systemic inflammation, is associated with fracture risk.
Pasco JA, Kotowicz MA, Henry MJ, Nicholson GC, Spilsbury HJ, Box JD, Schneider HG. High-Sensitivity C-Reactive Protein and Fracture Risk in Elderly Women. JAMA. 2006;296(11):1349-1355. doi:10.1001/jama.296.11.1353