In Reply: The meta-analysis that we conducted in 19971 included the available evidence from placebo-controlled trials of β-blockers and diuretics. Dr Messerli and colleagues question whether the findings of Lindholm et al2 actually confirm ours. Regarding the placebo-controlled trials of β-blockers, our findings agree with Figure 2A in Lindholm et al. For example, in both meta-analyses, β-blockers compared with placebo were associated with a reduced risk of stroke but not coronary disease.1,2 The 1997 JNC 6 recommendations3 were appropriately evidence-based, using the clinical trial findings of an actual health benefit as evidence.
Psaty BM, Weiss NS, Furberg CD. Clinical Trials in Hypertension—Reply. JAMA. 2006;296(12):1463-1465. doi:10.1001/jama.296.12.1464-b