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October 4, 2006

Complexity of the Cerebral Palsy SyndromesToward a Developmental Neuroscience Approach

Author Affiliations

Author Affiliations: Kennedy Mental Retardation Center and the Institute of Molecular Pediatrics, University of Chicago Pritzker School of Medicine, University of Chicago Comer Children's and LaRabida Children's Hospitals, Chicago, Ill.

JAMA. 2006;296(13):1650-1652. doi:10.1001/jama.296.13.1650

Over the past 2 decades, major advances in obstetrics, genetics, maternal fetal medicine, neonatology, developmental neurosciences, and reproductive epidemiology112 have resulted in unprecedented low rates of infant mortality. In 2004, the overall US infant mortality rate was 7 per 1000, with 90% survival of children born very prematurely at 28 to 32 weeks of gestation and survival as high as 80% for children born extremely prematurely at 24 to 28 weeks.13,14 In addition, a new consensus definition of cerebral palsy (CP) has been proposed,15 advances in neuroimaging1620 have allowed for the examination of central nervous system structure, and a gross motor function classification system21,22 has given neurodevelopmental pediatricians, orthopedic surgeons, and physical therapists a common language for interdisciplinary collaboration.

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