Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: In the Combined Pharmacotherapies and Behavioral Interventions (COMBINE) Study, Dr Anton and colleagues1 evaluated the effects of combining medications with behavioral interventions in treatment of alcohol dependence. While all 9 study groups showed marked reductions in drinking from baseline to end of study, treatment with acamprosate, naltrexone, or both when added to the background of medical management did not substantially improve percent days abstinent or time to first heavy drinking day (the 2 coprimary outcomes) compared with placebo and medical management, regardless of whether a combined behavioral intervention (CBI) was added.
Jonas JM, Chabac S. Pharmacotherapy and Behavioral Intervention for Alcohol Dependence. JAMA. 2006;296(14):1727-1729. doi:10.1001/jama.296.14.1727-a