Letters Section Editor: Robert M. Golub, MD, Senior Editor.
In Reply: Drs Jonas and Chabac assert that the COMBINE Study is not broadly relevant because (1) the findings were unexpected and contradict prior studies; (2) the study had a data collection rate higher than those of previous acamprosate trials; (3) the medical management intervention was intensive and not feasible; (4) the cohort was highly selected; and (5) outcomes were unusually good in the placebo group. Drs Kiefer and Mann assert that acamprosate might have been found effective if we had selected patients who were more severely dependent or in need of medical alcohol detoxification.
Anton RF, Miller WR, O’Malley SS, Zweben A, Hosking JD. Pharmacotherapy and Behavioral Intervention for Alcohol Dependence—Reply. JAMA. 2006;296(14):1727-1729. doi:10.1001/jama.296.14.1728