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October 18, 2006

High-Dose Statins and Atherosclerosis Regression

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(15):1836-1837. doi:10.1001/jama.296.15.1837-a

To the Editor: Dr Nissen and colleagues1 reported coronary plaque regression as a result of high-dose statin therapy. In their “Comment” section, Figure 3 illustrates the relationship between achieved LDL-C levels and changes in plaque size using intravascular ultrasound, based on data from 3 randomized pharmacological intervention trials. It appears that an LDL-C value of 76 mg/dL was the cutoff at which the linear regression analysis predicted no plaque increase: the transition from progression to regression.

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