Letters Section Editor: Robert M. Golub, MD, Senior Editor.
In Reply: Drs Aspray and Unwin raise questions about the difficulty in extrapolating evidence from younger to older patients. It is important to consider more broadly that clinicians must make a calculated guess when translating the average effect of an intervention measured for a population studied in a clinical trial to an individual patient in a practice, irrespective of the age difference.1
Durso SC. Clinical Guidelines for Older Adults With Diabetes Mellitus—Reply. JAMA. 2006;296(15):1839-1840. doi:10.1001/jama.296.15.1840-a