Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: We would like to raise possible reasons for the treatment failure of granulocyte colony-stimulating factor (G-CSF) in the Regenerate Vital Myocardium by Vigorous Activation of Bone Marrow Stem Cells (REVIVAL-2) trial by Dr Zohlnhöfer and colleagues1 based on what we believe to be the mechanism of action of G-CSF in both the myocardium and the brain.
Schäbitz W, Nikol S, Schneider A. Granulocyte Colony-Stimulating Factor and Acute Myocardial Infarction. JAMA. 2006;296(16):1967-1969. doi:10.1001/jama.296.16.1967