October 25, 2006

Granulocyte Colony-Stimulating Factor and Acute Myocardial Infarction

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(16):1967-1969. doi:10.1001/jama.296.16.1968-a

To the Editor: The clinical trial of G-CSF therapy for patients with AMI by Dr Zohlnhöfer and colleagues1 showed that when compared with placebo, the therapy had no benefit in terms of infarct size and left ventricular function. Another trial also failed to show any functional improvement after AMI with G-CSF treatment.2 These results suggest that there might be some unknown mechanisms undermining the therapy.

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