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Medical News and Perspectives
November 8, 2006

Panel Clarifies NSAID Benefits and Risks

JAMA. 2006;296(18):2193. doi:10.1001/jama.296.18.2193

Most physicians are aware of the positive and negative consequences associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), but the American Gastroenterology Association (AGA) believes clinicians should be more familiar than they currently are about the risks associated with specific NSAIDs, the magnitude of risks, and ways to reduce such risks.

To that end, the AGA has compiled a set of recommendations from a cross-disciplinary panel to serve as a template for treating patients with NSAIDs, from aspirin to the cyclooxygenase 2 (COX-2) inhibitors (Wilcox CM et al. Clin Gastroenterol Hepatol. 2006;4:1082-1089). The document focuses on gastrointestinal toxicity associated with NSAID use but also highlights cardiovascular risks and benefits associated with these medications.

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