Author Affiliations: Department of Medicine (Drs Lewis and Legato) and Department of Urology and Male Reproductive Center (Dr Fisch), Columbia University Medical Center/New York Presbyterian Hospital, New York, NY.
The phrase “biological clock” is most commonly used by physicians to refer to the declining fertility, increasing risk for fetal birth defects, and altered hormone levels experienced by women as they age. Abundant scientific evidence suggests that men also may have a biological clock.1,2 Men and their physicians must therefore understand the effects of the male biological clock on sexual and reproductive health, as well as its potential contributions to major medical consequences such as diabetes, cardiovascular disease, and the metabolic syndrome.
Lewis BH, Legato M, Fisch H. Medical Implications of the Male Biological Clock. JAMA. 2006;296(19):2369-2371. doi:10.1001/jama.296.19.2369