The Cover Section Editor: M. Therese Southgate, MD, Senior Contributing Editor.
Domenico Ghirlandaio (1449-1494), son of Tommaso del Ghirlandaio, a goldsmith who had invented the ornamental garlands (ghirlanda) worn by fashionable Florentine women, was born in Florence at almost the exact midpoint of the period that has come to be known as the Early Renaissance. Already under way for some 50 years, it would be another 50 before the period culminated in the High Renaissance, and that would occur not in Florence but in Rome, for the very practical reason that that was where the money was. The Medici, who had sponsored the revival of learning in their city for nearly the entire 15th century, had been forced out of Florence and commissions were no longer forthcoming. Younger artists such as Raphael and Michelangelo turned to the papacy in Rome for support.
Southgate MT. Portrait of a Lady. JAMA. 2006;296(23):2771. doi:10.1001/jama.296.23.2771