Letters Section Editor: Robert M. Golub, MD, Senior Editor.
In Reply: In our Commentary, we explicitly focused on the clinical use of genomic test panels and not on their use for discovery in population studies. For the latter studies we firmly believe that a broad, comprehensive, multivariate approach with careful analysis is desirable. Measuring thousands of genetic variants in large populations can establish the probabilistic dependencies on which rational sequential testing strategies for clinical diagnostics can be developed.
Kohane IS, Masys DR, Altman RB. The Incidentalome—Reply. JAMA. 2006;296(23):2800-2802. doi:10.1001/jama.296.23.2801-b