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Letters
January 3, 2007

Fluid Replacement for Severe Hyponatremia—Reply

JAMA. 2007;297(1):41-42. doi:10.1001/jama.297.1.41-b

In Reply: Dr Moritz raises concerns about the safety of infusing 3% sodium chloride (12 mL/kg) over a 4-hour period in the management of seizure associated with severe hyponatremia. This was a phase 4 study to determine if routine use of a new formulation of reduced osmolarity oral rehydration solution (compared with a previous formulation) would be associated with symptomatic hyponatremia; unlike physiological studies, it did not have the provision for frequent monitoring of serum electrolytes.

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