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Medical News and Perspectives
January 3, 2007

Arthritis Clinical Trial Results Revealed

JAMA. 2007;297(1):28-29. doi:10.1001/jama.297.1.28

Washington, DC—Late-breaking research presented at the recent annual conference of the American College of Rheumatology and the Association of Rheumatology Health Professionals highlighted results from phase 2 and 3 clinical trials testing experimental agents to treat arthritis. Candidates ranged from the nonspecific anti-inflammatory chondroitin sulfate to biologic agents that target specific immune response modifiers.

RHEUMATOID ARTHRITIS AGENTS

For rheumatoid arthritis, a disease characterized by immune and/or inflammatory responses gone awry, researchers are testing the potential of a number of therapies that target immune response modifiers, such as cytokines and their cell receptors. An international team of investigators reported results from a randomized, double-blind, placebo-controlled phase 2a trial of a drug called CP-690,550, which inhibits a receptor for several interleukins and had shown efficacy in targeting this receptor (Janus kinase 3) in rodent models of arthritis and in humans with psoriasis.

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