JAMA 100 Years Ago Section Editor: Jennifer Reiling, Assistant Editor.
It would be strange if a disease which is so widespread and so well known among the laity as appendicitis should have escaped the notice of the daily press. In fact, it has been of late years a frequent topic of discussion, and only recently the newspapers were commenting on an article which appeared in the London Lancet suggesting a connection between appendicitis and the prevalent use of boric acid as a food preservative. The article admitted that little had been shown beyond the fact that the use of boric acid and the increase in appendicitis had occurred during the same period, and that boric acid in exceptionally large quantities could cause a condition favorable to appendicitis.
FANTASTIC THEORIES OF THE CAUSE OF APPENDICITIS.. JAMA. 2007;297(2):221. doi:10.1001/jama.297.2.221