Letters Section Editor: Robert M. Golub, MD, Senior Editor.
In Reply: Drs Boffetta, Tarone, and Blot raised several points regarding our results. They suggest that the nodules detected via CT may not be clinically important, so that the findings may represent overdiagnosis. However, we studied patients who had lung cancer diagnosed in growing nodules, confirmed by a panel of pulmonary pathologists. To their point that available evidence from observational studies may not support a conclusion that CT detection reduces mortality, that was not the study question in this article. Regarding the possibility of differential detection of clinically unimportant lesions by sex, the relevant question here is whether there is a sex difference in the propensity to diagnose lung cancer, as we discussed in the Comment section of our article.
Miettinen OS, Henschke CI. Survival in Women After Diagnosis of Lung Cancer—Reply. JAMA. 2007;297(2):153-154. doi:10.1001/jama.297.2.153-c