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January 17, 2007

Fixed-Dose Unfractionated Heparin vs Low-Molecular-Weight Heparin for Venous Thromboembolism

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(3):261-263. doi:10.1001/jama.297.3.261-a

To the Editor: Dr Kearon and colleagues1 compared the use of fixed-dose, weight-adjusted unfractionated heparin and low-molecular-weight heparin for acute venous thromboembolism (VTE). One of the key findings was the small risk of major bleeding at 10 days, although there was a non–statistically significant difference at 3 months (1.7% for the unfractionated heparin group vs 3.4% for the low-molecular-weight heparin group).

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