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January 17, 2007

Fixed-Dose Unfractionated Heparin vs Low-Molecular-Weight Heparin for Venous Thromboembolism

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(3):261-263. doi:10.1001/jama.297.3.262-b

To the Editor: In their study comparing fixed-dosed unfractionated heparin with low-molecular-weight heparin for the treatment of VTE, Dr Kearon and colleagues1 concluded that fixed-dose subcutaneous unfractionated heparin was as safe and effective as low-molecular-weight-heparin for the initial treatment of patients with acute VTE. This conclusion was based on the results of a well-designed and conducted noninferiority trial that met prespecified margins of absolute difference for the primary end points.

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