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February 14, 2007

Targeted Treatment of Active Trachoma

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(6):588-590. doi:10.1001/jama.285.6.734

To the Editor: Dr Atik and colleagues1 studied the prevalence of active trachoma and ocular Chlamydia trachomatis infection in 3 Vietnamese communes. Two communes (Surgery for trachomatous trichiasis; Antibiotics for Chlamydia trachomatis infection; [SA], and Surgery for trachomatous trichiasis; Antibiotics for Chlamydia trachomatis infection; Facial cleanliness; Environmental improvement [SAFE])were selected to receive azithromycin using a targeted approach in which schoolchildren aged 5 to 15 years with signs of active trachoma and their household contacts were treated. A third commune that did not receive oral antibiotics served as a control. Because no association was found between clinical signs and the presence of ocular C trachomatis infection, only a small proportion of infected individuals was treated with azithromycin: 4% and 11% of the 2 SA and SAFE communes, respectively, at baseline; and 0% and 10% at 1 year.

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