[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Medical News and Perspectives
February 14, 2007

Virulence of 1918 Influenza Virus Linked to Inflammatory Innate Immune Response

JAMA. 2007;297(6):580. doi:10.1001/jama.297.6.580

With its predilection for striking young and healthy adults more than children and the elderly, the 1918 “Spanish” influenza virus is believed to have differed from contemporary strains in its mechanism of action. New research is now illuminating this mechanism, pointing to viral effects that activated the innate immune response to levels that were so damaging to the lungs that acute respiratory distress, severe tissue damage, edema and hemorrhage, and pneumonia resulted in many individuals (Kobasa D et al. Nature. 2007;45:319-323).

First Page Preview View Large
First page PDF preview
First page PDF preview