Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: In their study, Dr Rodriguez and colleagues1 challenge the long-held view that baseline plasma HIV-1 RNA level is the best predictor of the rate of CD4 cell decline among untreated HIV-infected individuals, initially put forward by Mellors et al in 1997.2 There are several methodological issues that may have contributed to this controversy.
Lima VD, Hogg RS, Montaner JSG. Presenting Plasma HIV RNA Level and Rate of CD4 T-Cell Decline. JAMA. 2007;297(8):805-807. doi:10.1001/jama.297.8.805-b