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February 28, 2007

Presenting Plasma HIV RNA Level and Rate of CD4 T-Cell Decline—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(8):805-807. doi:10.1001/jama.297.8.807-a

In Reply: Dr Gottlieb and colleagues raise important and valid points regarding the study by Dr Rodriguez and colleagues1 and our editorial. They correctly point out that the study focused exclusively on the relationship between plasma HIV-1 RNA levels and the decline in CD4 T-cell counts. They note that the lower viremia levels seen with HIV-2 infection appear to be directly related to the difference in pathogenicity between HIV-1 and HIV-2, and that when adjusted for plasma viral load, a similar rate of CD4 T-cell decline is seen in patients infected with HIV-1 and HIV-2.2,3

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