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Lab Reports
March 7, 2007

Reactivating

JAMA. 2007;297(9):941. doi:10.1001/jama.297.9.941-c

While scientists have known that the p53 tumor suppressor gene plays an important role in the development of many different tumor types and is mutated or inactivated in more than half of human cancers, they had not known whether restoring its normal function could reverse tumor growth. Now, however, researchers at the Massachusetts Institute of Technology, in Cambridge, Mass, have demonstrated that activating expression of p53 in mouse sarcomas and lymphomas reduced the size of the tumors, in some cases eliminating them (Ventura A et al. Nature. doi:10.1038/nature05541 [published online January 24, 2007]).

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