Letters Section Editor: Robert M. Golub, MD, Senior Editor.
In Reply: Drs Guntheroth and Spiers argue that the medullary 5-HT abnormalities observed in the infants with SIDS in our study were due to the effects of hypoxia prior to death and were not the cause of death. We did not conclude that the abnormality of serotonin function in the brainstem is a specific cause of SIDS, rather that it is associated with SIDS. We agree that whether the serotonin abnormality is a cause or effect of any insult, including hypoxia, cannot be established with certainty in an autopsy study.
Paterson DS. Sudden Infant Death Syndrome and Brain Abnormalities—Reply. JAMA. 2007;297(11):1190-1191. doi:10.1001/jama.297.11.1191-a