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The World in Medicine
March 21, 2007

Microbicide Trial Stopped

JAMA. 2007;297(11):1182. doi:10.1001/jama.297.11.1182-c

A major phase 3 trial of a microbicide gel being tested in Africa and India for its ability to prevent HIV infection was halted prematurely after interim safety monitoring revealed that a higher number of HIV infections occurred in those who received the gel compared with those who were given a placebo gel, according to United Nations agencies (http://www.who.int/hiv/mediacentre/news65/en/). Previous safety and contraceptive trials of the cellulose sulfate (a cotton-based compound) gel had not identified safety concerns.

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