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March 28, 2007

Pioglitazone vs Glimepiride and Carotid Intima-Media Thickness

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(12):1315-1317. doi:10.1001/jama.297.12.1316-a

To the Editor: Dr Mazzone and colleagues1 showed that pioglitazone slowed progression of CIMT compared with glimepiride in patients with type 2 diabetes. The absolute change of CIMT was used as the primary end point instead of the number of cardiovascular events because CIMT is strongly associated with risk of future cardiovascular events.2

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