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March 28, 2007

Polymorphisms in the

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(12):1317-1318. doi:10.1001/jama.297.12.1317-a

To the Editor: In their study of polymorphisms in the C-reactive protein (CRP) gene, Dr Lange and colleagues1 found that genetic variation in the CRP gene was associated with CRP levels and that genetic variants were differentially associated with cardiovascular disease (CVD) events in white and black participants. The authors base their hypothesis on an analogous earlier study showing that the association of a PSSK9 variant with both low-density lipoprotein cholesterol (LDL-C) and CVD suggested that lifelong reduction in LDL-C would reduce CVD.

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