While adverse effects and drugs often go hand in hand, some of the complications that can arise from medication use have remained a mystery.
“A really big challenge in pharmacology is to establish which action of a drug is responsible for its clinical effect, whether it is a therapeutic or adverse effect,” said Solomon Snyder, MD, of the Johns Hopkins School of Medicine, in Baltimore.
Snyder and colleagues have taken on the challenge of elucidating an important adverse effect—major weight gain—often caused by certain atypical antipsychotic drugs (AAPDs) used for the treatment of schizophrenia (Kim SF et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.0611417104 [published online February 20, 2007]).
Hampton T. Antipsychotics’ Link to Weight Gain Found. JAMA. 2007;297(12):1305-1306. doi:10.1001/jama.297.12.1305