To the Editor: While secondary causes of osteoporosis frequently contribute to hip fractures,1,2 studies of these associations may be hampered by a lack of control for relevant confounding variables. In assessing the association of gastric acid suppression with hip fractures, Dr Yang and colleagues3 did not address vitamin D status as a potential confounder.
Geller JL, Adams JS. Proton Pump Inhibitor Therapy and Hip Fracture Risk. JAMA. 2007;297(13):1429-1430. doi:10.1001/jama.297.13.1429-a