Author Affiliation: Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Fla.
Type 1 diabetes mellitus (DM) arises from selective immunologically mediated destruction of the insulin-producing beta cells in the pancreatic islets of Langerhans with consequent insulin deficiency.1,2 This occurs in genetically susceptible individuals and is a cellular-mediated process, presumably a specific reaction to 1 or more beta cell proteins (autoantigens), although probably initiated by some environmental factors. There is consequent progressive impairment of beta cell function and decline in beta cell mass.
Skyler JS. Cellular Therapy for Type 1 DiabetesHas the Time Come?. JAMA. 2007;297(14):1599-1600. doi:10.1001/jama.297.14.1599