Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: In studying the appropriate duration of dual antiplatelet therapy in patients with DES, Dr Eisenstein and colleagues1 report the results obtained from the analysis of a large registry of patients who underwent intracoronary stents. They found that in patients with DES, extended use of clopidogrel with aspirin appears to be associated with a reduction in rates of death, as well as the composite outcome of death or myocardial infarction. While these results provide value while waiting for an eventual randomized clinical trial, they would be more interpretable with additional information.
Matteau A, LeLorier J. Clopidogrel and Long-term Outcomes After Drug-Eluting Stent Implantation. JAMA. 2007;297(16):1769-1771. doi:10.1001/jama.297.16.1770-a