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Lab Reports
May 2, 2007

Cancer-Suppressing Mutation

JAMA. 2007;297(17):1870. doi:10.1001/jama.297.17.1870-a

New research has identified a gene that, when mutated, may suppress colorectal cancer. Scientists from Thomas Jefferson University, in Philadelphia, found that when mice that are prone to developing polyps in the digestive tract possess only 1 copy of the mutated gene (mice with 2 copies of the mutation die during embryonic development), the incidence of intestinal polyps is reduced by about 90% (Baran AA et al. Genome Res. doi:10.1101/gr .6089707 [published online ahead of print March 26, 2007]).

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