[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
Lab Reports
May 2, 2007

Cancer-Suppressing Mutation

JAMA. 2007;297(17):1870. doi:10.1001/jama.297.17.1870-a

New research has identified a gene that, when mutated, may suppress colorectal cancer. Scientists from Thomas Jefferson University, in Philadelphia, found that when mice that are prone to developing polyps in the digestive tract possess only 1 copy of the mutated gene (mice with 2 copies of the mutation die during embryonic development), the incidence of intestinal polyps is reduced by about 90% (Baran AA et al. Genome Res. doi:10.1101/gr .6089707 [published online ahead of print March 26, 2007]).

First Page Preview View Large
First page PDF preview
First page PDF preview