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May 2, 2007

Treatment of Depression in Patients With Coronary Artery Disease

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(17):1878-1880. doi:10.1001/jama.297.17.1879

To The Editor: The report of the CREATE trial by Dr Lespérance and colleagues1 concluded that citalopram was superior to placebo and found no benefit for interpersonal therapy over clinical management. It is encouraging that the patients in this study responded within 12 weeks to the combination of antidepressant and clinical management, since depression is an independent risk factor for coronary artery disease. We are concerned, however, that readers may dismiss the value of psychotherapy for depression in this population. There are some strong arguments for the use of psychotherapy in conjunction with pharmacotherapy to treat depression.

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