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Letters
May 2, 2007

Pexelizumab and the APEX AMI Trial—Reply

Author Affiliations
 

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(17):1881-1882. doi:10.1001/jama.297.17.1881-c

In Reply: The completion of the PRIMO-CABG II trial1,2 at a time when enrollment into the APEX AMI trial was still in progress enabled the steering committee and the trial sponsors to refine their estimates of the probability of detecting a clinically important benefit of pexelizumab on mortality. However, the reduction in sample size that occurred following their reassessment meant that the APEX AMI trial had only a 52% power to detect a 24% reduction in mortality at 30 days.

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