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May 9, 2007

Use of Alendronate After 5 Years of Treatment

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(18):1979-1981. doi:10.1001/jama.297.18.1979-a

To the Editor: In the conclusions of the report on the Fracture Intervention Trial (FIT) Long-term Extension (FLEX), Dr Black and colleagues1 state that “the results confirm the safety of alendronate for up to 10 years including no increased fracture risk with long-term alendronate use.”1 However, we do not believe that this study design warrants this conclusion. There is no group that received only placebo; those patients included in the “placebo” group had previously received alendronate for a mean of 5 years. Therefore, long-term alendronate safety cannot be determined from this study and requires a different trial.

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