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May 9, 2007

Use of Alendronate After 5 Years of Treatment

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(18):1979-1981. doi:10.1001/jama.297.18.1979-b

To the Editor: In the FLEX study, Dr Black and colleagues1 investigated the effects of discontinuation of alendronate in women following 5 years of use. There was no significant difference between the morphometric vertebral fracture rates in the group that switched to placebo and in the group that continued to receive alendronate. However, the percentage of clinically recognized vertebral fractures was greater in the placebo group.

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