Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: The iron-heart hypothesis postulated a primary protective effect of iron depletion against ischemic heart disease.1 The report of the Iron (Fe) and Atherosclerosis Study (FeAST) by Dr Zacharski and colleagues2 had 2 key limitations as a general test of the idea: it was a trial of secondary prevention, and the iron-reduction protocol fell short of achieving full iron depletion.
Sullivan JL, Katz SD. Iron Reduction and Cardiovascular Outcomes. JAMA. 2007;297(19):2075-2076. doi:10.1001/jama.297.19.2075-a