Medical News and Perspectives
May 16, 2007

Common Gene Variant Linked to Obesity

JAMA. 2007;297(19):2063-2064. doi:10.1001/jama.297.19.2063

A large meta-analysis of research articles has pointed to a common variant of a gene that may predispose some individuals to obesity. While the variant was associated with only a modest increase in weight gain, it appears to cause obesity in a population already experiencing excess weight gain, the study investigators said (Frayling TM et al. Science. doi:10.1126/science.1141634 [published online April 12, 2007]).


It was during a genome-wide search for type 2 diabetes susceptibility genes that a team of scientists, primarily in the United Kingdom, first identified this variant, which lies within the FTO gene on chromosome 16.

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