Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: Dr Nicholls and colleagues1 found that treatment with statins was associated with regression of coronary atherosclerosis (assessed by intravascular ultrasonography) when low-density lipoprotein cholesterol (LDL-C) was substantially reduced and high-density lipoprotein cholesterol (HDL-C) was increased by more than 7.5%. The authors state that it remains to be determined whether these changes translate to improved clinical outcomes because the small increases in HDL-C observed during statin therapy have never been shown to correlate with clinical outcome.
Athyros VG, Kakafika A, Karagiannis A, Mikhailidis DP. Statins and Regression of Coronary Atherosclerosis. JAMA. 2007;297(20):2197. doi:10.1001/jama.297.20.2197-a