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Medical News and Perspectives
May 23/30, 2007

Malaria Researchers Target Mosquitoes

JAMA. 2007;297(20):2187. doi:10.1001/jama.297.20.2187

Malaria researchers studying the Anopheles mosquito's physiology, behavior, and ecology are hoping such studies will lead to improved methods for controlling the disease.

One promising approach involves the creation of transgenic mosquitoes that are resistant to infection with the malarial parasite. Researchers at Johns Hopkins Malaria Research Institute, in Baltimore, recently found that a malaria-resistant designer mosquito they developed in 2002 could outcompete its wild-type counterparts when fed malaria-infected blood from mice (Marrelli MT et al. Proc Natl Acad Sci U S A. 2007;104:5580-5583). The nonresistant mosquitoes carrying parasites laid fewer eggs and did not live as long as the transgenic mosquitoes.

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