A study funded by the National Institute of Child Health and Human Development is designed to determine which of the 2 drugs commonly prescribed to treat status epilepticus in children is safer and more effective. Status epilepticus affects up to 8 in 1000 children before they reach age 15 years and is fatal in 4% of cases.
The study will be conducted at 11 hospitals in which children presenting to the emergency departments with status epilepticus will be randomly assigned to either diazepam or lorazepam (http://www.nichd.nih.gov/news/releases/study_pediatric_seizure_QA_052207.cfm). Diazepam is approved for use in adults and children while lorazepam is approved for adults but is being used off label for children.
Mitka M. Pediatric Seizure Drugs Tested. JAMA. 2007;297(24):2686. doi:10.1001/jama.297.24.2686-a