A more humanlike mouse model of cancer could enhance cancer gene discovery and improve the predictive value of laboratory drug testing, according to scientists who developed the model.
The researchers, led by a team at the Dana-Farber Cancer Institute, in Boston, genetically modified a strain of lymphoma-prone mice so that the animals had chromosomal instability. By comparing the patterns of chromosomal changes in the mice with patterns observed in more than 400 human tumor specimens (including melanoma, lung, colon, and pancreatic cancers, and multiple myeloma), they found that the cancers that developed acquired widespread recurrent amplifications and deletions at genetic sites that are often altered in human tumors (Maser RS et al. Nature. doi:10.1038/nature05886 [published online ahead of print May 21, 2007]).
Hampton T. New Cancer Research Tool. JAMA. 2007;298(1):32. doi:10.1001/jama.298.1.32-a